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dc.date.available
2023-04-20T18:50:56Z
dc.identifier.citation
Denninghoff, Valeria Cecilia; Fresno Rodríguez, Cristóbal; (2023): S1 File: Cohort database. Consejo Nacional de Investigaciones Científicas y Técnicas. (dataset). http://hdl.handle.net/11336/194798
dc.identifier.uri
http://hdl.handle.net/11336/194798
dc.description.abstract
The Human Papillomavirus (HPV) test is a crucial technology for cervical cancer prevention because it enables programs to identify women with high-risk HPV infection who are at risk of developing cervical cancer. Current U.S. Preventive Services Task Force recommendations include cervical cancer screening every three years with cervical cytology alone or every five years with either high-risk HPV testing alone or high-risk HPV testing combined with cytology (co-testing). In Argentina, 7,548 new cervical cancer cases are diagnosed each year with 3,932 deaths attributed to this cause. Our study aims to show the clinical implementation of a cervical cancer screening program by concurrent HPV testing and cervical cytology (co-testing); and to evaluate the possible cervical cancer screening scenarios for Latin America, focusing on their performance and average cost. A cervical cancer screening five year program via co-testing algorithm (Hybrid-2-Capture/cytology) was performed on women aged 30-65 years old at a university hospital. Statistical analysis included a multinomial logistic regression, and two cancer screening classification alternatives were tested (cytology-reflex and HPV-reflex). A total of 2,273 women were included, 91.11% of the participants were double-negative, 2.55% double-positive, 5.90% positive-Hybrid-2-Capture-/negative-cytology, and 0.44% negative-Hybrid-2-Capture/positive-cytology. A thorough follow-up was performed in the positive-Hybrid-2-Capture group. Despite our efforts, 21 (10.93%) were lost, mainly because of changes on their health insurance coverage which excluded them from our screening algorithm. Of the 171 women with positive-Hybrid-2-Capture results and follow-up, 68 (39.77%) cleared the virus infection, 64 (37.43%) showed viral persistence, and 39 (22.81%) were adequately treated after detection via colposcopy/biopsy of histological HSIL (High-Grade Squamous Intraepithelial Lesion). The prevalence of high-risk HPV in this population was 192 women (8.45%), with HSIL histology detection rates of 17.32 per 1,000 screened women. A multinomial logistic regression analysis was performed over the women with positive-Hybrid-2-Capture considering the follow up (clearance, persistence and HSIL) as dependent variable, and the cytology test results (positive- or negative-cytology and Atypical Squamous Cells of Undetermined Significance, ASC-US) as independent variable. The model supported a direct association between cytology test results and follow up: negative-cytology/clearance, ASC-US/persistence, and positive-cytology/HSIL with the following probabilities of occurrence for these pairs 0.5, 0.647 and 0.647, respectively. Cytology could be considered a prognostic-factor in women with a positive-Hybrid-2-Capture. These findings suggest that the introduction of co-testing could diminish the burden of cervical cancer in low-and middle-income-countries, acting as a tool against inequity in healthcare.
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.title
S1 File: Cohort database
dc.type
dataset
dc.date.updated
2023-03-17T12:44:19Z
dc.description.fil
Fil: Denninghoff, Valeria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Fresno Rodríguez, Cristóbal. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Anahuac Mexico; México
dc.rights.license
Protección de datos personales (Ley 25.326)
dc.datacite.PublicationYear
2023
dc.datacite.Creator
Denninghoff, Valeria Cecilia
dc.datacite.Creator
Fresno Rodríguez, Cristóbal
dc.datacite.affiliation
Consejo Nacional de Investigaciones Científicas y Técnicas
dc.datacite.affiliation
Consejo Nacional de Investigaciones Científicas y Técnicas
dc.datacite.affiliation
Universidad Anahuac Mexico
dc.datacite.publisher
Consejo Nacional de Investigaciones Científicas y Técnicas
dc.datacite.subject
Obstetricia y Ginecología
dc.datacite.subject
Medicina Clínica
dc.datacite.subject
CIENCIAS MÉDICAS Y DE LA SALUD
dc.datacite.date
01/12/2022
dc.datacite.DateType
Creado
dc.datacite.language
eng
dc.datacite.AlternateIdentifierType
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1371/journal.pone.0278476
dc.datacite.version
1.0
dc.datacite.description
https://journals.plos.org/plosone/article/file?type=supplementary&id=10.1371/journal.pone.0278476.s001
dc.datacite.DescriptionType
Información de Series
dc.relationtype.isSourceOf
http://dx.doi.org/10.1371/journal.pone.0278476
dc.subject.keyword
HPV Human Papillomavirus
dc.subject.keyword
HC2 Hybrid-2-Capture
dc.subject.keyword
Cervical cancer
dc.subject.keyword
Low-income country
dc.datacite.resourceTypeGeneral
dataset
dc.conicet.datoinvestigacionid
5722
dc.datacite.geolocation
Buenos Aires
dc.datacite.formatedDate
2022
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