Raw data from Novack et al. (2025): "The supramolecular architecture of mitochondrial complex I in the rat brain is altered by Alzheimer's-like cerebral amyloidosis" published in Journal of Neurochemistry, 169(2):e70017

Abstract

This dataset corresponds to the raw data from which Figures 1, 2, 3, 4, 5, 6, 7 and 9, Supplementary Figures S1, S3, S4, S5 and S6 and Supplementary Table 1 from the paper by Novack et al. (2025) "The Supramolecular Architecture of Mitochondrial Complex I in the Rat Brain Is Altered by Alzheimer's-Like Cerebral Amyloidosis" published in Journal of Neurochemistry 169(2):e70017. doi: 10.1111/jnc.70017. This work is part of the doctoral thesis of the first author (Dr. Gisela Vanina Novack) and was carried out under the supervision of Dr. Laura Morelli at the Laboratory of Brain Aging and Neurodegeneration (Head: Eduardo M. Castaño) of the Leloir Institute Foundation (IIBBA-CONICET). This work has characterized the types, abundance and activity of mitochondrial supercomplexes (SCs) in the hippocampus of an animal model of cerebral amyloidosis, providing further experimental evidence for the molecular mechanisms underlying the brain bioenergetic deficit characteristic of Alzheimer's disease.