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dc.date.available
2022-04-18T17:07:23Z
dc.identifier.citation
Kembro, Jackelyn Melissa; Aon, Miguel Antonio; Cortassa, Sonia del Carmen; Lloyd, David; Sollott, Steven; (2022): Chaotic fluctuations in mitochondrial function under oxidative stress. Superoxide dismutatase (SOD2) concentrations of 0.013, 0.016,0.0164, 0.0216733 mM. Consejo Nacional de Investigaciones Científicas y Técnicas. (dataset). http://hdl.handle.net/11336/155280
dc.identifier.uri
http://hdl.handle.net/11336/155280
dc.description.abstract
These chaotic time series of mitochondrial dynamics under conditions of oxidative stress are analyzed in detail in Kembro et al. 2018. Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability. Mitochondrial model used was described in the project overview and in detail (Kembro et al. 2013. Biophys J 104(2):332-343; Kembro et al., 2014. Front Physiol 5:257).
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.title
Chaotic fluctuations in mitochondrial function under oxidative stress. Superoxide dismutatase (SOD2) concentrations of 0.013, 0.016,0.0164, 0.0216733 mM
dc.type
dataset
dc.date.updated
2022-04-01T19:29:50Z
dc.description.fil
Fil: Kembro, Jackelyn Melissa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
dc.description.fil
Fil: Aon, Miguel Antonio. University Johns Hopkins; Estados Unidos
dc.description.fil
Fil: Cortassa, Sonia del Carmen. University Johns Hopkins; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Lloyd, David. Cardiff University; Reino Unido
dc.description.fil
Fil: Sollott, Steven. National Institute on Aging; Estados Unidos
dc.datacite.PublicationYear
2022
dc.datacite.Creator
Kembro, Jackelyn Melissa
dc.datacite.Creator
Aon, Miguel Antonio
dc.datacite.Creator
Cortassa, Sonia del Carmen
dc.datacite.Creator
Lloyd, David
dc.datacite.Creator
Sollott, Steven
dc.datacite.affiliation
Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas
dc.datacite.affiliation
University Johns Hopkins
dc.datacite.affiliation
University Johns Hopkins
dc.datacite.affiliation
Consejo Nacional de Investigaciones Científicas y Técnicas
dc.datacite.affiliation
Cardiff University
dc.datacite.affiliation
National Institute on Aging
dc.datacite.publisher
Consejo Nacional de Investigaciones Científicas y Técnicas
dc.datacite.subject
Biología
dc.datacite.subject
Ciencias Biológicas
dc.datacite.subject
CIENCIAS NATURALES Y EXACTAS
dc.datacite.date
01/01/2017-31/12/2017
dc.datacite.DateType
Creado
dc.datacite.language
eng
dc.datacite.AlternateIdentifierType
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.6084/m9.figshare.7117808
dc.datacite.AlternateIdentifierType
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.6084/m9.figshare.7117907
dc.datacite.AlternateIdentifierType
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.6084/m9.figshare.7117910
dc.datacite.AlternateIdentifierType
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.6084/m9.figshare.7117913
dc.datacite.AlternateIdentifierType
info:eu-repo/semantics/altIdentifier/hdl/http://hdl.handle.net/11086/17029
dc.datacite.AlternateIdentifierType
info:eu-repo/semantics/altIdentifier/hdl/http://hdl.handle.net/11086/17030
dc.datacite.AlternateIdentifierType
info:eu-repo/semantics/altIdentifier/hdl/http://hdl.handle.net/11086/16807
dc.datacite.AlternateIdentifierType
info:eu-repo/semantics/altIdentifier/hdl/http://hdl.handle.net/11086/16912
dc.datacite.version
1.0
dc.datacite.description
Numerical integration of the ME-R model equations was performed with MatCont 2.4 in MATLAB 7.1, until steady-state solutions were obtained (i.e., when the magnitude of each time derivative was -10). Time series with duration of at least 6e6 ms were constructed by numerical integration of model equations. To allow transient states to vanish, the system was computed during a time lapse of 2 e8 ms.All studies were performed using the parameter setting optimized in our previous work (Kembro et al. 2013. Biophys J 104(2):332-343; Kembro et al., 2014. Front Physiol 5:257), with ADPm = 0.01mM, i.e. consistent with energized mitochondria under state 4 respiration. The two .txt file represents the time reference and the time series of variables output of the model, in order from left to right column: 1) Mitochondrial Ca+;2) Mitochondrial ADP; 3) Membrane potential; 4)Mitocondrial NADH; 5) Mitochondrial H+; 6) Mitochondrial Phosfate, Pi; 7) Isocitrate; 8) a-ketoglutarate; 9) Succinyl CoA; 10) Succinate; 11) Fumarate; 12) Malate; 13) Oxaloacetate; 14) NADPH; 15) Mitochondrial superoxide; 16) Extramitochondrial superoxide; 17) Mitochondrial hydrogen peroxide; 18) Extramitochondrial hydrogen peroxide; 19) Mitochondrial GSH; 20) Extramitochondrial GSH; 21)Mitochondrial GSSG; 22) Mitochondrial TrxSH2; 23) ExtramitochondrialTrxSH; 24)Mitochondrial PSSGm; 25) Extramitochondrial PSSG.
dc.datacite.description
Model-simulated time series were calculated with 0.013, 0.016, 0.0164, or 0.0216733 mM of SOD2, Shunt=0.04, SOD1 9.7 10-5 mM. External superoxide perturbation: amplitude=1 10-7 mM, period =30 s.
dc.datacite.DescriptionType
Información de Series
dc.datacite.DescriptionType
Información Técnica
dc.relationtype.isSourceOf
11336/24945
dc.relationtype.isSourceOf
11336/32229
dc.relationtype.isSourceOf
11336/87055
dc.subject.keyword
CHAOS
dc.subject.keyword
SERIE TIEMPO
dc.subject.keyword
MITOCONDRIA
dc.subject.keyword
ESTRES OXIDATIVO
dc.datacite.resourceTypeGeneral
dataset
dc.conicet.datoinvestigacionid
255
dc.conicet.justificacion
Son datos generado por modelado matematico
dc.datacite.formatedDate
2017
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